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BDBM50213742 2-(7-chloro-5-hydroxy-1,1-dioxo-1,4-dihydro-1lambda6-benzo[1,2,4]thiadiazin-3-ylamino)-benzoic acid::CHEMBL397809

SMILES: OC(=O)c1ccccc1NC1=Nc2c(O)cc(Cl)cc2S(=O)(=O)N1

InChI Key: InChIKey=HBQXDEUGYBDOOW-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50213742   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50213742
PNG
(2-(7-chloro-5-hydroxy-1,1-dioxo-1,4-dihydro-1lambd...)
Show SMILES OC(=O)c1ccccc1NC1=Nc2c(O)cc(Cl)cc2S(=O)(=O)N1 |t:11|
Show InChI InChI=1S/C14H10ClN3O5S/c15-7-5-10(19)12-11(6-7)24(22,23)18-14(17-12)16-9-4-2-1-3-8(9)13(20)21/h1-6,19H,(H,20,21)(H2,16,17,18)
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KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPR


Bioorg Med Chem Lett 17: 3864-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.011
BindingDB Entry DOI: 10.7270/Q21C1WKG
More data for this
Ligand-Target Pair