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BDBM50213754 3-(2-bromo-5-fluoro-phenylamino)-7-chloro-1,1-dioxo-1,4-dihydro-1lambda6-benzo[1,2,4]thiadiazin-5-ol::CHEMBL234596

SMILES: Oc1cc(Cl)cc2c1N=C(Nc1cc(F)ccc1Br)NS2(=O)=O

InChI Key: InChIKey=KSBSGEOBNFESAI-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50213754   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50213754
PNG
(3-(2-bromo-5-fluoro-phenylamino)-7-chloro-1,1-diox...)
Show SMILES Oc1cc(Cl)cc2c1N=C(Nc1cc(F)ccc1Br)NS2(=O)=O |t:9|
Show InChI InChI=1S/C13H8BrClFN3O3S/c14-8-2-1-7(16)5-9(8)17-13-18-12-10(20)3-6(15)4-11(12)23(21,22)19-13/h1-5,20H,(H2,17,18,19)
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KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.90E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPR


Bioorg Med Chem Lett 17: 3864-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.011
BindingDB Entry DOI: 10.7270/Q21C1WKG
More data for this
Ligand-Target Pair