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SMILES: Cc1cc(cc(C)n1)-c1c(F)cc2c(c1F)n(cc(Cc1ccc(O)cc1)c2=O)C1CC1

InChI Key: InChIKey=JCJHADVFGNFEMA-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50213810   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA topoisomerase 2-alpha/2-beta


(Homo sapiens (Human))		BDBM50213810
PNG
(CHEMBL7534)
Show SMILES Cc1cc(cc(C)n1)-c1c(F)cc2c(c1F)n(cc(Cc1ccc(O)cc1)c2=O)C1CC1
Show InChI InChI=1S/C26H22F2N2O2/c1-14-9-17(10-15(2)29-14)23-22(27)12-21-25(24(23)28)30(19-5-6-19)13-18(26(21)32)11-16-3-7-20(31)8-4-16/h3-4,7-10,12-13,19,31H,5-6,11H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
n/an/an/an/a 1.20E+3n/an/an/an/a


TBA

Assay Description
Inhibitory activity against HeLa cell Topoisomerase II

Citation and Details

BindingDB Entry DOI: 10.7270/Q2TX3HJW
More data for this
Ligand-Target Pair