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SMILES: Cc1cc(cc(C)n1)-c1c(F)cc2c(c1F)n(cc(Cc1ccccc1N)c2=O)C1CC1

InChI Key: InChIKey=PORMMXYUPVOUTC-UHFFFAOYSA-N

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50213811   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA topoisomerase 2-alpha/2-beta


(Homo sapiens (Human))		BDBM50213811
PNG
(CHEMBL7769)
Show SMILES Cc1cc(cc(C)n1)-c1c(F)cc2c(c1F)n(cc(Cc1ccccc1N)c2=O)C1CC1
Show InChI InChI=1S/C26H23F2N3O/c1-14-9-17(10-15(2)30-14)23-21(27)12-20-25(24(23)28)31(19-7-8-19)13-18(26(20)32)11-16-5-3-4-6-22(16)29/h3-6,9-10,12-13,19H,7-8,11,29H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem

Similars
n/an/an/an/a 2.10E+3n/an/an/an/a


TBA

Assay Description
Inhibitory activity against HeLa cell Topoisomerase II

Citation and Details

BindingDB Entry DOI: 10.7270/Q2TX3HJW
More data for this
Ligand-Target Pair