BDBM50213813 CHEMBL7960

SMILES: Cc1cc(cc(C)n1)-c1c(F)cc2c(c1F)n(cc(Cc1cccc(O)c1)c2=O)C1CC1

InChI Key: InChIKey=XXDJSHFEYIPUEZ-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50213813   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase 2-alpha/2-beta (Homo sapiens (Human))	BDBM50213813 (CHEMBL7960) Show SMILES Cc1cc(cc(C)n1)-c1c(F)cc2c(c1F)n(cc(Cc1cccc(O)c1)c2=O)C1CC1 Show InChI InChI=1S/C26H22F2N2O2/c1-14-8-17(9-15(2)29-14)23-22(27)12-21-25(24(23)28)30(19-6-7-19)13-18(26(21)32)10-16-4-3-5-20(31)11-16/h3-5,8-9,11-13,19,31H,6-7,10H2,1-2H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem		n/a	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity against HeLa cell Topoisomerase II				Citation and Details BindingDB Entry DOI: 10.7270/Q2TX3HJW
					More data for this Ligand-Target Pair