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BDBM50214363 3',6'-bis(dimethylamino)-N-[2-(4-methanesulfonamidophenoxy)ethyl]-N-[2-(4-methanesulfonamidophenyl)ethyl]-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-5-carboxamide::CHEMBL375513

SMILES: CN(C)c1ccc2c(Oc3cc(ccc3C22OC(=O)c3cc(ccc23)C(=O)N(CCOc2ccc(NS(C)(=O)=O)cc2)CCc2ccc(NS(C)(=O)=O)cc2)N(C)C)c1

InChI Key: InChIKey=MLWOLYKKTKCDPP-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50214363   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50214363
PNG
(3',6'-bis(dimethylamino)-N-[2-(4-methanesulfonamid...)
Show SMILES CN(C)c1ccc2c(Oc3cc(ccc3C22OC(=O)c3cc(ccc23)C(=O)N(CCOc2ccc(NS(C)(=O)=O)cc2)CCc2ccc(NS(C)(=O)=O)cc2)N(C)C)c1
Show InChI InChI=1S/C43H45N5O9S2/c1-46(2)32-14-19-37-39(26-32)56-40-27-33(47(3)4)15-20-38(40)43(37)36-18-9-29(25-35(36)42(50)57-43)41(49)48(22-21-28-7-10-30(11-8-28)44-58(5,51)52)23-24-55-34-16-12-31(13-17-34)45-59(6,53)54/h7-20,25-27,44-45H,21-24H2,1-6H3
PDB
MMDB

Reactome pathway
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UniProtKB/SwissProt

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DrugBank
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
>1.00E+3n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPA


J Med Chem 50: 2931-41 (2007)


Article DOI: 10.1021/jm0700565
BindingDB Entry DOI: 10.7270/Q2736RR2
More data for this
Ligand-Target Pair