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BDBM50214366 3,6-bis(dimethylamino)-N-(6-{[2-(4-methanesulfonamidophenoxy)ethyl][2-(4-methanesulfonamidophenyl)ethyl]amino}hexyl)-3'-oxo-3'H,10H-spiro[anthracene-9,1'-[2]benzofuran]-5'-carboxamide::CHEMBL375021

SMILES: CN(C)c1ccc2c(Cc3cc(ccc3C22OC(=O)c3cc(ccc23)C(=O)NCCCCCCN(CCOc2ccc(NS(C)(=O)=O)cc2)CCc2ccc(NS(C)(=O)=O)cc2)N(C)C)c1

InChI Key: InChIKey=IBAYMCMWLREABI-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50214366   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50214366
PNG
(3,6-bis(dimethylamino)-N-(6-{[2-(4-methanesulfonam...)
Show SMILES CN(C)c1ccc2c(Cc3cc(ccc3C22OC(=O)c3cc(ccc23)C(=O)NCCCCCCN(CCOc2ccc(NS(C)(=O)=O)cc2)CCc2ccc(NS(C)(=O)=O)cc2)N(C)C)c1
Show InChI InChI=1S/C50H60N6O8S2/c1-54(2)41-18-23-45-37(32-41)31-38-33-42(55(3)4)19-24-46(38)50(45)47-22-13-36(34-44(47)49(58)64-50)48(57)51-26-9-7-8-10-27-56(28-25-35-11-14-39(15-12-35)52-65(5,59)60)29-30-63-43-20-16-40(17-21-43)53-66(6,61)62/h11-24,32-34,52-53H,7-10,25-31H2,1-6H3,(H,51,57)
PDB
MMDB

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PC cid
PC sid
UniChem
Article
PubMed
89n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPA


J Med Chem 50: 2931-41 (2007)


Article DOI: 10.1021/jm0700565
BindingDB Entry DOI: 10.7270/Q2736RR2
More data for this
Ligand-Target Pair