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BDBM50214375 3',6'-dihydroxy-N-[2-(4-methanesulfonamidophenoxy)ethyl]-N-[2-(4-methanesulfonamidophenyl)ethyl]-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-5-carboxamide::CHEMBL390300

SMILES: CS(=O)(=O)Nc1ccc(CCN(CCOc2ccc(NS(C)(=O)=O)cc2)C(=O)c2ccc3c(c2)C(=O)OC32c3ccc(O)cc3Oc3cc(O)ccc23)cc1

InChI Key: InChIKey=UHWSRTCNJLGXHE-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50214375   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50214375
PNG
(3',6'-dihydroxy-N-[2-(4-methanesulfonamidophenoxy)...)
Show SMILES CS(=O)(=O)Nc1ccc(CCN(CCOc2ccc(NS(C)(=O)=O)cc2)C(=O)c2ccc3c(c2)C(=O)OC32c3ccc(O)cc3Oc3cc(O)ccc23)cc1
Show InChI InChI=1S/C39H35N3O11S2/c1-54(47,48)40-26-6-3-24(4-7-26)17-18-42(19-20-51-30-12-8-27(9-13-30)41-55(2,49)50)37(45)25-5-14-32-31(21-25)38(46)53-39(32)33-15-10-28(43)22-35(33)52-36-23-29(44)11-16-34(36)39/h3-16,21-23,40-41,43-44H,17-20H2,1-2H3
PDB
MMDB

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PC cid
PC sid
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Article
PubMed
980n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPA


J Med Chem 50: 2931-41 (2007)


Article DOI: 10.1021/jm0700565
BindingDB Entry DOI: 10.7270/Q2736RR2
More data for this
Ligand-Target Pair