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BDBM50215184 (R)-1-(2,6-difluorobenzyl)-6-(4-chlorobenzyl)-3-((1-(2-(pyridin-2-yl)ethyl)pyrrolidin-2-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione::CHEMBL236152

SMILES: Fc1cccc(F)c1Cn1c2CCN(Cc3ccc(Cl)cc3)Cc2c(=O)n(C[C@H]2CCCN2CCc2ccccn2)c1=O

InChI Key: InChIKey=RJMQDUQSQDWCOB-AREMUKBSSA-N

Data: 1 KI

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50215184   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Gonadotropin releasing hormone 1 (GnRHR1)


(Homo sapiens (Human))
BDBM50215184
PNG
((R)-1-(2,6-difluorobenzyl)-6-(4-chlorobenzyl)-3-((...)
Show SMILES Fc1cccc(F)c1Cn1c2CCN(Cc3ccc(Cl)cc3)Cc2c(=O)n(C[C@H]2CCCN2CCc2ccccn2)c1=O
Show InChI InChI=1S/C33H34ClF2N5O2/c34-24-11-9-23(10-12-24)19-38-17-14-31-28(21-38)32(42)41(33(43)40(31)22-27-29(35)7-3-8-30(27)36)20-26-6-4-16-39(26)18-13-25-5-1-2-15-37-25/h1-3,5,7-12,15,26H,4,6,13-14,16-22H2/t26-/m1/s1
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
10n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Displacement of [125I-His5,D-Tyr6]GnRH from human cloned GnRH receptor transfected in COS7 cells


Bioorg Med Chem 15: 5590-603 (2007)


Article DOI: 10.1016/j.bmc.2007.05.029
BindingDB Entry DOI: 10.7270/Q2VH5NJG
More data for this
Ligand-Target Pair