BDBM50215406 (1'R,2'S,4'S,5'S)-4-(2-ethynyl-6-methylaminopurin-9-yl)-1-[(phosphato)-methyl]-2-(phosphato)-bicyclo[3.1.0]hexane::CHEMBL390149
SMILES: CNc1nc(nc2n(cnc12)[C@H]1C[C@H](OP(O)(O)=O)[C@]2(COP(O)(O)=O)C[C@H]12)C#C
InChI Key: InChIKey=JVOQZLLPAUDWBN-HTQGBYLWSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Purinergic receptor P2Y1 (Homo sapiens (Human)) | BDBM50215406 ((1'R,2'S,4'S,5'S)-4-(2-ethynyl-6-methylaminopurin-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 95 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Displacement of [3H]MRS2270 from human P2Y1 receptor expressed in Sf9 cells | J Med Chem 50: 3229-41 (2007) Article DOI: 10.1021/jm0700971 BindingDB Entry DOI: 10.7270/Q2BK1C2D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purinergic receptor P2Y1 (Homo sapiens (Human)) | BDBM50215406 ((1'R,2'S,4'S,5'S)-4-(2-ethynyl-6-methylaminopurin-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Antagonist activity at human P2Y1 receptor expressed in 1321N1 cells assessed as inhibition of 2-MeS-ADP-stimulated PLC activity | J Med Chem 50: 3229-41 (2007) Article DOI: 10.1021/jm0700971 BindingDB Entry DOI: 10.7270/Q2BK1C2D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purinergic receptor P2Y1 (Homo sapiens (Human)) | BDBM50215406 ((1'R,2'S,4'S,5'S)-4-(2-ethynyl-6-methylaminopurin-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Antagonist activity at human P2Y1 receptor expressed in 1321N1 cells assessed as inhibition of 2-MeSADP-induced inositol phosphate formation | J Med Chem 50: 3229-41 (2007) Article DOI: 10.1021/jm0700971 BindingDB Entry DOI: 10.7270/Q2BK1C2D | |||||||||||
More data for this Ligand-Target Pair |