BDBM50215706 CHEMBL399315::sodium (3R,5R)-7-(5-((3-methoxybenzyl)carbamoyl)-3-(4-fluorophenyl)-1-isopropyl-4-phenyl-1H-pyrrol-2-yl)-3,5-dihydroxyheptanoate

SMILES: COc1cccc(CNC(=O)c2c(c(c(CC[C@@H](O)C[C@@H](O)CC([O-])=O)n2C(C)C)-c2ccc(F)cc2)-c2ccccc2)c1

InChI Key: InChIKey=NZMZYAIECCYZQJ-VSGBNLITSA-M

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50215706   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) (Homo sapiens (Human))	BDBM50215706 (CHEMBL399315 | sodium (3R,5R)-7-(5-((3-methoxybenz...) Show SMILES COc1cccc(CNC(=O)c2c(c(c(CC[C@@H](O)C[C@@H](O)CC([O-])=O)n2C(C)C)-c2ccc(F)cc2)-c2ccccc2)c1 Show InChI InChI=1S/C35H39FN2O6/c1-22(2)38-30(17-16-27(39)19-28(40)20-31(41)42)32(25-12-14-26(36)15-13-25)33(24-9-5-4-6-10-24)34(38)35(43)37-21-23-8-7-11-29(18-23)44-3/h4-15,18,22,27-28,39-40H,16-17,19-21H2,1-3H3,(H,37,43)(H,41,42)/p-1/t27-,28-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Inhibition of HMG-CoA reductase				Bioorg Med Chem Lett 17: 4538-44 (2007) Article DOI: 10.1016/j.bmcl.2007.05.096 BindingDB Entry DOI: 10.7270/Q2SJ1K9Q
					More data for this Ligand-Target Pair