BDBM50215750 6-methoxy-2-(4-(2-(pyridin-3-yl)vinyl)-1H-pyrazol-3-yl)-1H-benzo[d]imidazole::CHEMBL428225

SMILES: COc1ccc2nc([nH]c2c1)-c1n[nH]cc1C=Cc1cccnc1

InChI Key: InChIKey=WENOTWRMBOBLIZ-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50215750   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50215750 (6-methoxy-2-(4-(2-(pyridin-3-yl)vinyl)-1H-pyrazol-...) Show SMILES COc1ccc2nc([nH]c2c1)-c1n[nH]cc1C=Cc1cccnc1 |w:17.20| Show InChI InChI=1S/C18H15N5O/c1-24-14-6-7-15-16(9-14)22-18(21-15)17-13(11-20-23-17)5-4-12-3-2-8-19-10-12/h2-11H,1H3,(H,20,23)(H,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	970	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development L.L.C. Curated by ChEMBL					Assay Description Inhibition of VEGFR2				Bioorg Med Chem Lett 17: 4557-61 (2007) Article DOI: 10.1016/j.bmcl.2007.05.092 BindingDB Entry DOI: 10.7270/Q2DB81JD
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50215750 (6-methoxy-2-(4-(2-(pyridin-3-yl)vinyl)-1H-pyrazol-...) Show SMILES COc1ccc2nc([nH]c2c1)-c1n[nH]cc1C=Cc1cccnc1 |w:17.20| Show InChI InChI=1S/C18H15N5O/c1-24-14-6-7-15-16(9-14)22-18(21-15)17-13(11-20-23-17)5-4-12-3-2-8-19-10-12/h2-11H,1H3,(H,20,23)(H,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development L.L.C. Curated by ChEMBL					Assay Description Inhibition of aurora-A				Bioorg Med Chem Lett 17: 4557-61 (2007) Article DOI: 10.1016/j.bmcl.2007.05.092 BindingDB Entry DOI: 10.7270/Q2DB81JD
					More data for this Ligand-Target Pair				3D Structure (docked)
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50215750 (6-methoxy-2-(4-(2-(pyridin-3-yl)vinyl)-1H-pyrazol-...) Show SMILES COc1ccc2nc([nH]c2c1)-c1n[nH]cc1C=Cc1cccnc1 |w:17.20| Show InChI InChI=1S/C18H15N5O/c1-24-14-6-7-15-16(9-14)22-18(21-15)17-13(11-20-23-17)5-4-12-3-2-8-19-10-12/h2-11H,1H3,(H,20,23)(H,21,22)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development L.L.C. Curated by ChEMBL					Assay Description Inhibition of HER2				Bioorg Med Chem Lett 17: 4557-61 (2007) Article DOI: 10.1016/j.bmcl.2007.05.092 BindingDB Entry DOI: 10.7270/Q2DB81JD
					More data for this Ligand-Target Pair