BDBM50215752 6-(4-methylpiperazin-1-yl)-2-(4-(2-(pyridin-3-yl)vinyl)-1H-pyrazol-3-yl)-1H-benzo[d]imidazole::CHEMBL394465

SMILES: CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1n[nH]cc1C=Cc1cccnc1

InChI Key: InChIKey=LTPJBJXFWRHNJB-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50215752   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase A (Homo sapiens (Human))	BDBM50215752 (6-(4-methylpiperazin-1-yl)-2-(4-(2-(pyridin-3-yl)v...) Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1n[nH]cc1C=Cc1cccnc1 |w:22.26| Show InChI InChI=1S/C22H23N7/c1-28-9-11-29(12-10-28)18-6-7-19-20(13-18)26-22(25-19)21-17(15-24-27-21)5-4-16-3-2-8-23-14-16/h2-8,13-15H,9-12H2,1H3,(H,24,27)(H,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development L.L.C. Curated by ChEMBL					Assay Description Inhibition of aurora-A				Bioorg Med Chem Lett 17: 4557-61 (2007) Article DOI: 10.1016/j.bmcl.2007.05.092 BindingDB Entry DOI: 10.7270/Q2DB81JD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50215752 (6-(4-methylpiperazin-1-yl)-2-(4-(2-(pyridin-3-yl)v...) Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1n[nH]cc1C=Cc1cccnc1 |w:22.26| Show InChI InChI=1S/C22H23N7/c1-28-9-11-29(12-10-28)18-6-7-19-20(13-18)26-22(25-19)21-17(15-24-27-21)5-4-16-3-2-8-23-14-16/h2-8,13-15H,9-12H2,1H3,(H,24,27)(H,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development L.L.C. Curated by ChEMBL					Assay Description Inhibition of VEGFR2				Bioorg Med Chem Lett 17: 4557-61 (2007) Article DOI: 10.1016/j.bmcl.2007.05.092 BindingDB Entry DOI: 10.7270/Q2DB81JD
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50215752 (6-(4-methylpiperazin-1-yl)-2-(4-(2-(pyridin-3-yl)v...) Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1n[nH]cc1C=Cc1cccnc1 |w:22.26| Show InChI InChI=1S/C22H23N7/c1-28-9-11-29(12-10-28)18-6-7-19-20(13-18)26-22(25-19)21-17(15-24-27-21)5-4-16-3-2-8-23-14-16/h2-8,13-15H,9-12H2,1H3,(H,24,27)(H,25,26)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development L.L.C. Curated by ChEMBL					Assay Description Inhibition of HER2				Bioorg Med Chem Lett 17: 4557-61 (2007) Article DOI: 10.1016/j.bmcl.2007.05.092 BindingDB Entry DOI: 10.7270/Q2DB81JD
					More data for this Ligand-Target Pair