BDBM50215757 3-(2-(3-(4-(trifluoromethyl)-1H-imidazol-2-yl)-1H-pyrazol-4-yl)vinyl)pyridine::CHEMBL246165

SMILES: FC(F)(F)c1cnc([nH]1)-c1n[nH]cc1C=Cc1cccnc1

InChI Key: InChIKey=OKRLCDNMDXJZIY-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50215757   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50215757 (3-(2-(3-(4-(trifluoromethyl)-1H-imidazol-2-yl)-1H-...) Show SMILES FC(F)(F)c1cnc([nH]1)-c1n[nH]cc1C=Cc1cccnc1 |w:15.17| Show InChI InChI=1S/C14H10F3N5/c15-14(16,17)11-8-19-13(21-11)12-10(7-20-22-12)4-3-9-2-1-5-18-6-9/h1-8H,(H,19,21)(H,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development L.L.C. Curated by ChEMBL					Assay Description Inhibition of VEGFR2				Bioorg Med Chem Lett 17: 4557-61 (2007) Article DOI: 10.1016/j.bmcl.2007.05.092 BindingDB Entry DOI: 10.7270/Q2DB81JD
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50215757 (3-(2-(3-(4-(trifluoromethyl)-1H-imidazol-2-yl)-1H-...) Show SMILES FC(F)(F)c1cnc([nH]1)-c1n[nH]cc1C=Cc1cccnc1 |w:15.17| Show InChI InChI=1S/C14H10F3N5/c15-14(16,17)11-8-19-13(21-11)12-10(7-20-22-12)4-3-9-2-1-5-18-6-9/h1-8H,(H,19,21)(H,20,22)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development L.L.C. Curated by ChEMBL					Assay Description Inhibition of HER2				Bioorg Med Chem Lett 17: 4557-61 (2007) Article DOI: 10.1016/j.bmcl.2007.05.092 BindingDB Entry DOI: 10.7270/Q2DB81JD
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50215757 (3-(2-(3-(4-(trifluoromethyl)-1H-imidazol-2-yl)-1H-...) Show SMILES FC(F)(F)c1cnc([nH]1)-c1n[nH]cc1C=Cc1cccnc1 |w:15.17| Show InChI InChI=1S/C14H10F3N5/c15-14(16,17)11-8-19-13(21-11)12-10(7-20-22-12)4-3-9-2-1-5-18-6-9/h1-8H,(H,19,21)(H,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development L.L.C. Curated by ChEMBL					Assay Description Inhibition of aurora-A				Bioorg Med Chem Lett 17: 4557-61 (2007) Article DOI: 10.1016/j.bmcl.2007.05.092 BindingDB Entry DOI: 10.7270/Q2DB81JD
					More data for this Ligand-Target Pair