BDBM50215784 4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)-N-(2-hydroxyethyl)picolinamide::CHEMBL246608

SMILES: OCCNC(=O)c1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1

InChI Key: InChIKey=XTMWIEVQVYQIFB-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50215784   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50215784 (4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carba...) Show SMILES OCCNC(=O)c1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 Show InChI InChI=1S/C23H20F2N4O5/c24-23(25)33-19-6-5-15(12-20(19)34-23)29-21(31)16-3-1-2-4-17(16)28-13-14-7-8-26-18(11-14)22(32)27-9-10-30/h1-8,11-12,28,30H,9-10,13H2,(H,27,32)(H,29,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant cKit by FRET assay				Bioorg Med Chem Lett 17: 4378-81 (2007) Article DOI: 10.1016/j.bmcl.2007.02.075 BindingDB Entry DOI: 10.7270/Q28K78S7
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50215784 (4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carba...) Show SMILES OCCNC(=O)c1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 Show InChI InChI=1S/C23H20F2N4O5/c24-23(25)33-19-6-5-15(12-20(19)34-23)29-21(31)16-3-1-2-4-17(16)28-13-14-7-8-26-18(11-14)22(32)27-9-10-30/h1-8,11-12,28,30H,9-10,13H2,(H,27,32)(H,29,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	397	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of b-Raf				Bioorg Med Chem Lett 17: 4378-81 (2007) Article DOI: 10.1016/j.bmcl.2007.02.075 BindingDB Entry DOI: 10.7270/Q28K78S7
					More data for this Ligand-Target Pair