BDBM50215792 4-((5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)thiazol-4-ylamino)methyl)-N-methylpicolinamide::CHEMBL247248

SMILES: CNC(=O)c1cc(CNc2ncsc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1

InChI Key: InChIKey=GXFMUXGPPXGMTM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50215792   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50215792 (4-((5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carba...) Show SMILES CNC(=O)c1cc(CNc2ncsc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 Show InChI InChI=1S/C19H15F2N5O4S/c1-22-17(27)12-6-10(4-5-23-12)8-24-16-15(31-9-25-16)18(28)26-11-2-3-13-14(7-11)30-19(20,21)29-13/h2-7,9,24H,8H2,1H3,(H,22,27)(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.24E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of b-Raf				Bioorg Med Chem Lett 17: 4378-81 (2007) Article DOI: 10.1016/j.bmcl.2007.02.075 BindingDB Entry DOI: 10.7270/Q28K78S7
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50215792 (4-((5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carba...) Show SMILES CNC(=O)c1cc(CNc2ncsc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 Show InChI InChI=1S/C19H15F2N5O4S/c1-22-17(27)12-6-10(4-5-23-12)8-24-16-15(31-9-25-16)18(28)26-11-2-3-13-14(7-11)30-19(20,21)29-13/h2-7,9,24H,8H2,1H3,(H,22,27)(H,26,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant cKit by FRET assay				Bioorg Med Chem Lett 17: 4378-81 (2007) Article DOI: 10.1016/j.bmcl.2007.02.075 BindingDB Entry DOI: 10.7270/Q28K78S7
					More data for this Ligand-Target Pair