BDBM50215938 CHEMBL53373

SMILES: CCc1cn(c2cc(ccc12)C(=O)Nc1c(Cl)cncc1Cl)S(=O)(=O)c1ccc(C)cc1

InChI Key: InChIKey=UABXQCCWRDSYTF-UHFFFAOYSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50215938   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50215938 (CHEMBL53373) Show SMILES CCc1cn(c2cc(ccc12)C(=O)Nc1c(Cl)cncc1Cl)S(=O)(=O)c1ccc(C)cc1 Show InChI InChI=1S/C23H19Cl2N3O3S/c1-3-15-13-28(32(30,31)17-7-4-14(2)5-8-17)21-10-16(6-9-18(15)21)23(29)27-22-19(24)11-26-12-20(22)25/h4-13H,3H2,1-2H3,(H,26,27,29)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	>3.75E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rh£ne-Poulenc Rorer Central Research Curated by ChEMBL					Assay Description Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assay				Bioorg Med Chem Lett 8: 1867-72 (1998) BindingDB Entry DOI: 10.7270/Q2CJ8GPB
					More data for this Ligand-Target Pair
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50215938 (CHEMBL53373) Show SMILES CCc1cn(c2cc(ccc12)C(=O)Nc1c(Cl)cncc1Cl)S(=O)(=O)c1ccc(C)cc1 Show InChI InChI=1S/C23H19Cl2N3O3S/c1-3-15-13-28(32(30,31)17-7-4-14(2)5-8-17)21-10-16(6-9-18(15)21)23(29)27-22-19(24)11-26-12-20(22)25/h4-13H,3H2,1-2H3,(H,26,27,29)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Rh£ne-Poulenc Rorer Central Research Curated by ChEMBL					Assay Description Inhibitory activity against Phosphodiesterase type IV (PDE4) obtained from guinea-pig macrophage was evaluated				Bioorg Med Chem Lett 8: 1867-72 (1998) BindingDB Entry DOI: 10.7270/Q2CJ8GPB
					More data for this Ligand-Target Pair