BindingDB PrimarySearch

BDBM50216502 4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester::CHEMBL236789::monastrol::rac-monastrol

SMILES: CCOC(=O)C1C(NC(=S)N=C1C)c1cccc(O)c1

InChI Key: InChIKey=PSKVISJISBFCKP-UHFFFAOYSA-N

Data: 11 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50216502
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Kinesin-like protein KIFC1 (Homo sapiens (Human))	BDBM50216502 (4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tet...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal His6-tagged KIFC1 (Q305-K673 aa) (unknown origin) expressed in Escherichia coli BL21 (DE3) by malachite green as...				J Med Chem 57: 9958-70 (2014) Article DOI: 10.1021/jm501179r BindingDB Entry DOI: 10.7270/Q2QF8VG8
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair
Kinesin-like protein 1 (Homo sapiens (Human))	BDBM50216502 (4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tet...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
CNRS-Université Louis Pasteur Curated by ChEMBL					Assay Description Inhibition of Eg5 ATPase activity expressed in Escherichia coli after 12 hrs				Bioorg Med Chem 15: 6474-88 (2007) Article DOI: 10.1016/j.bmc.2007.06.016 BindingDB Entry DOI: 10.7270/Q2X63MPM
CNRS-Université Louis Pasteur Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Kinesin-like protein 1 (Homo sapiens (Human))	BDBM50216502 (4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tet...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
CNRS-Université Louis Pasteur Curated by ChEMBL					Assay Description Inhibition of Eg5 ATPase activity expressed in HeLa cells after 12 hrs				Bioorg Med Chem 15: 6474-88 (2007) Article DOI: 10.1016/j.bmc.2007.06.016 BindingDB Entry DOI: 10.7270/Q2X63MPM
CNRS-Université Louis Pasteur Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Kinesin-like protein 1 (Homo sapiens (Human))	BDBM50216502 (4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tet...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.23E+4	n/a	n/a	n/a	n/a	n/a	n/a
CNRS-Université Louis Pasteur Curated by ChEMBL					Assay Description Inhibition of microtubule-stimulated Eg5 ATPase activity expressed in Escherichia coli after 12 hrs				Bioorg Med Chem 15: 6474-88 (2007) Article DOI: 10.1016/j.bmc.2007.06.016 BindingDB Entry DOI: 10.7270/Q2X63MPM
CNRS-Université Louis Pasteur Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Kinesin-like protein 1 (Homo sapiens (Human))	BDBM50216502 (4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tet...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.47E+3	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human full-length Eg5 ATPase activity expressed in Escherichia coli assessed as release of inorganic phosphate after 30 mins				Bioorg Med Chem 18: 8035-43 (2010) Article DOI: 10.1016/j.bmc.2010.09.020 BindingDB Entry DOI: 10.7270/Q2BZ668Q
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Kinesin-like protein 1 (Homo sapiens (Human))	BDBM50216502 (4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tet...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tanta University Curated by ChEMBL					Assay Description Inhibition of recombinant human His-tagged Eg5 (1 to 368 residues) assessed as reduction in ATPase activity by Bradford reagent based assay				Bioorg Med Chem 27: (2019) Article DOI: 10.1016/j.bmc.2019.115126
Tanta University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Kinesin-like protein 1 (Homo sapiens (Human))	BDBM50216502 (4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tet...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.45E+3	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human ATPase activity KSP expressed in Escherichia coli after 30 mins by spectrophotometric analysis				Bioorg Med Chem 19: 5612-27 (2011) Article DOI: 10.1016/j.bmc.2011.07.029 BindingDB Entry DOI: 10.7270/Q2B858HD
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Kinesin-like protein 1 (Homo sapiens (Human))	BDBM50216502 (4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tet...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Indian Institute of Chemical Technology Curated by ChEMBL					Assay Description Inhibition of HsEg5				Eur J Med Chem 46: 3274-81 (2011) Article DOI: 10.1016/j.ejmech.2011.04.048 BindingDB Entry DOI: 10.7270/Q2T1541D
Indian Institute of Chemical Technology Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Kinesin-like protein 1 (Homo sapiens (Human))	BDBM50216502 (4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tet...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Cairo University Curated by ChEMBL					Assay Description Inhibition of Eg5 (unknown origin)				Eur J Med Chem 62: 614-31 (2013) Article DOI: 10.1016/j.ejmech.2013.01.031 BindingDB Entry DOI: 10.7270/Q2KH0PP9
Cairo University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Kinesin-like protein 1 (Homo sapiens (Human))	BDBM50216502 (4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tet...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
CSIR-Central Drug Research Institute Curated by ChEMBL					Assay Description Inhibition of Eg5 (unknown origin)				Eur J Med Chem 60: 120-7 (2013) Article DOI: 10.1016/j.ejmech.2012.11.044 BindingDB Entry DOI: 10.7270/Q24M95VR
CSIR-Central Drug Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Aurora kinase A (Homo sapiens (Human))	BDBM50216502 (4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tet...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human purified recombinant aurora-A kinase				Bioorg Med Chem 18: 8035-43 (2010) Article DOI: 10.1016/j.bmc.2010.09.020 BindingDB Entry DOI: 10.7270/Q2BZ668Q
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair