Found 6 hits for monomerid = 50216790 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Matrix metalloproteinase-14
(Homo sapiens (Human)) | BDBM50216790
((3R)-6-cyclohexyl-3-[3-(2,4-dioxo-1,2,3,4-tetrahyd...)Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(no1)-c1c[nH]c(=O)[nH]c1=O Show InChI InChI=1S/C18H25N5O5/c24-14(22-27)9-12(8-4-7-11-5-2-1-3-6-11)17-20-15(23-28-17)13-10-19-18(26)21-16(13)25/h10-12,27H,1-9H2,(H,22,24)(H2,19,21,25,26)/t12-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of MMP14 |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Matrix metalloproteinase-9
(Homo sapiens (Human)) | BDBM50216790
((3R)-6-cyclohexyl-3-[3-(2,4-dioxo-1,2,3,4-tetrahyd...)Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(no1)-c1c[nH]c(=O)[nH]c1=O Show InChI InChI=1S/C18H25N5O5/c24-14(22-27)9-12(8-4-7-11-5-2-1-3-6-11)17-20-15(23-28-17)13-10-19-18(26)21-16(13)25/h10-12,27H,1-9H2,(H,22,24)(H2,19,21,25,26)/t12-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of MMP9 |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Stromelysin-1
(Homo sapiens (Human)) | BDBM50216790
((3R)-6-cyclohexyl-3-[3-(2,4-dioxo-1,2,3,4-tetrahyd...)Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(no1)-c1c[nH]c(=O)[nH]c1=O Show InChI InChI=1S/C18H25N5O5/c24-14(22-27)9-12(8-4-7-11-5-2-1-3-6-11)17-20-15(23-28-17)13-10-19-18(26)21-16(13)25/h10-12,27H,1-9H2,(H,22,24)(H2,19,21,25,26)/t12-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of MMP3 |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 1
(Homo sapiens (Human)) | BDBM50216790
((3R)-6-cyclohexyl-3-[3-(2,4-dioxo-1,2,3,4-tetrahyd...)Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(no1)-c1c[nH]c(=O)[nH]c1=O Show InChI InChI=1S/C18H25N5O5/c24-14(22-27)9-12(8-4-7-11-5-2-1-3-6-11)17-20-15(23-28-17)13-10-19-18(26)21-16(13)25/h10-12,27H,1-9H2,(H,22,24)(H2,19,21,25,26)/t12-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human procollagen C-proteinase expressed in CHO cells |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Collagenase 3
(Homo sapiens (Human)) | BDBM50216790
((3R)-6-cyclohexyl-3-[3-(2,4-dioxo-1,2,3,4-tetrahyd...)Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(no1)-c1c[nH]c(=O)[nH]c1=O Show InChI InChI=1S/C18H25N5O5/c24-14(22-27)9-12(8-4-7-11-5-2-1-3-6-11)17-20-15(23-28-17)13-10-19-18(26)21-16(13)25/h10-12,27H,1-9H2,(H,22,24)(H2,19,21,25,26)/t12-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.96E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of MMP13 |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50216790
((3R)-6-cyclohexyl-3-[3-(2,4-dioxo-1,2,3,4-tetrahyd...)Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(no1)-c1c[nH]c(=O)[nH]c1=O Show InChI InChI=1S/C18H25N5O5/c24-14(22-27)9-12(8-4-7-11-5-2-1-3-6-11)17-20-15(23-28-17)13-10-19-18(26)21-16(13)25/h10-12,27H,1-9H2,(H,22,24)(H2,19,21,25,26)/t12-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7.96E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of MMP2 |
J Med Chem 50: 3442-56 (2007)
Article DOI: 10.1021/jm061010z
BindingDB Entry DOI: 10.7270/Q2W66KGB |
More data for this
Ligand-Target Pair | |
Search and Browse
