BDBM50216823 2-(5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl}-1,2,4-oxadiazol-3-yl)isonicotinic acid::CHEMBL226853

SMILES: ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(no1)-c1cc(ccn1)C(O)=O

InChI Key: InChIKey=BCLDMTLBRZOHBQ-CQSZACIVSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50216823   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bone morphogenetic protein 1 (Homo sapiens (Human))	BDBM50216823 (2-(5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoe...) Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(no1)-c1cc(ccn1)C(O)=O Show InChI InChI=1S/C20H26N4O5/c25-17(23-28)12-14(8-4-7-13-5-2-1-3-6-13)19-22-18(24-29-19)16-11-15(20(26)27)9-10-21-16/h9-11,13-14,28H,1-8,12H2,(H,23,25)(H,26,27)/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human procollagen C-proteinase expressed in CHO cells				J Med Chem 50: 3442-56 (2007) Article DOI: 10.1021/jm061010z BindingDB Entry DOI: 10.7270/Q2W66KGB
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50216823 (2-(5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoe...) Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(no1)-c1cc(ccn1)C(O)=O Show InChI InChI=1S/C20H26N4O5/c25-17(23-28)12-14(8-4-7-13-5-2-1-3-6-13)19-22-18(24-29-19)16-11-15(20(26)27)9-10-21-16/h9-11,13-14,28H,1-8,12H2,(H,23,25)(H,26,27)/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of MMP2				J Med Chem 50: 3442-56 (2007) Article DOI: 10.1021/jm061010z BindingDB Entry DOI: 10.7270/Q2W66KGB
					More data for this Ligand-Target Pair
Zinc metalloproteinase dpy-31 (Brugia malayi)	BDBM50216823 (2-(5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoe...) Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(no1)-c1cc(ccn1)C(O)=O Show InChI InChI=1S/C20H26N4O5/c25-17(23-28)12-14(8-4-7-13-5-2-1-3-6-13)19-22-18(24-29-19)16-11-15(20(26)27)9-10-21-16/h9-11,13-14,28H,1-8,12H2,(H,23,25)(H,26,27)/t14-/m1/s1	MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Glasgow Curated by ChEMBL					Assay Description Inhibition of recombinant Brugia malayi DPY-31 astacin domain expressed in Escherichia coli using Suc-Ala-Ala-Ala-pNA as substrate preincubated for 3...				Bioorg Med Chem Lett 25: 5752-5 (2015) Article DOI: 10.1016/j.bmcl.2015.10.077 BindingDB Entry DOI: 10.7270/Q21839JQ
					More data for this Ligand-Target Pair
Zinc metalloproteinase dpy-31 (Teladorsagia circumcincta)	BDBM50216823 (2-(5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoe...) Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(no1)-c1cc(ccn1)C(O)=O Show InChI InChI=1S/C20H26N4O5/c25-17(23-28)12-14(8-4-7-13-5-2-1-3-6-13)19-22-18(24-29-19)16-11-15(20(26)27)9-10-21-16/h9-11,13-14,28H,1-8,12H2,(H,23,25)(H,26,27)/t14-/m1/s1	MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.98E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Glasgow Curated by ChEMBL					Assay Description Inhibition of recombinant Teladorsagia circumcincta DPY-31 astacin domain expressed in Escherichia coli using Suc-Ala-Ala-Ala-pNA as substrate preinc...				Bioorg Med Chem Lett 25: 5752-5 (2015) Article DOI: 10.1016/j.bmcl.2015.10.077 BindingDB Entry DOI: 10.7270/Q21839JQ
					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50216823 (2-(5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoe...) Show SMILES ONC(=O)C[C@@H](CCCC1CCCCC1)c1nc(no1)-c1cc(ccn1)C(O)=O Show InChI InChI=1S/C20H26N4O5/c25-17(23-28)12-14(8-4-7-13-5-2-1-3-6-13)19-22-18(24-29-19)16-11-15(20(26)27)9-10-21-16/h9-11,13-14,28H,1-8,12H2,(H,23,25)(H,26,27)/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of MMP1				J Med Chem 50: 3442-56 (2007) Article DOI: 10.1021/jm061010z BindingDB Entry DOI: 10.7270/Q2W66KGB
					More data for this Ligand-Target Pair