BDBM50217366 4-(6-amino-5-((methoxyimino)methyl)pyrimidin-4-yl)-N-(4-isopropylphenyl)piperazine-1-carboxamide::CHEMBL391368
SMILES: CO\N=C\c1c(N)ncnc1N1CCN(CC1)C(=O)Nc1ccc(cc1)C(C)C
InChI Key: InChIKey=BETGUWIXNZCDCM-WYMPLXKRSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM50217366 (4-(6-amino-5-((methoxyimino)methyl)pyrimidin-4-yl)...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson and Johnson Pharmaceutical Research and Development LLC Curated by ChEMBL | Assay Description Inhibition of human FLT3 | Bioorg Med Chem Lett 17: 4861-5 (2007) Article DOI: 10.1016/j.bmcl.2007.06.046 BindingDB Entry DOI: 10.7270/Q2T72H47 | |||||||||||
More data for this Ligand-Target Pair |