BDBM50217367 4-(6-amino-5-((methoxyimino)methyl)pyrimidin-4-yl)-N-(4-(pyrrolidin-1-yl)phenyl)piperazine-1-carboxamide::CHEMBL401046

SMILES: CO\N=C\c1c(N)ncnc1N1CCN(CC1)C(=O)Nc1ccc(cc1)N1CCCC1

InChI Key: InChIKey=NGTMSDLBZFUAFC-AFUMVMLFSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50217367   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50217367 (4-(6-amino-5-((methoxyimino)methyl)pyrimidin-4-yl)...) Show SMILES CO\N=C\c1c(N)ncnc1N1CCN(CC1)C(=O)Nc1ccc(cc1)N1CCCC1 Show InChI InChI=1S/C21H28N8O2/c1-31-25-14-18-19(22)23-15-24-20(18)28-10-12-29(13-11-28)21(30)26-16-4-6-17(7-5-16)27-8-2-3-9-27/h4-7,14-15H,2-3,8-13H2,1H3,(H,26,30)(H2,22,23,24)/b25-14+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development LLC Curated by ChEMBL					Assay Description Inhibition of human FLT3				Bioorg Med Chem Lett 17: 4861-5 (2007) Article DOI: 10.1016/j.bmcl.2007.06.046 BindingDB Entry DOI: 10.7270/Q2T72H47
					More data for this Ligand-Target Pair