BDBM50217485 CHEMBL394229::N-((3R,6S)-1-(cyclopropylmethyl)-2-oxo-6-phenylazepan-3-yl)-4-(2-oxo-1,2,4,5-tetrahydrobenzo[d][1,3]diazepin-3-yl)piperidine-1-carboxamide
SMILES: O=C(N[C@@H]1CC[C@H](CN(CC2CC2)C1=O)c1ccccc1)N1CCC(CC1)N1CCc2ccccc2NC1=O
InChI Key: InChIKey=GKEYVYYYUKUCAC-LEAFIULHSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM50217485 (CHEMBL394229 | N-((3R,6S)-1-(cyclopropylmethyl)-2-...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Displacement of [125I]CGRP from human CL receptor in RAMP1 membranes | Bioorg Med Chem Lett 17: 4795-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.062 BindingDB Entry DOI: 10.7270/Q2JS9Q4D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM50217485 (CHEMBL394229 | N-((3R,6S)-1-(cyclopropylmethyl)-2-...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP production | Bioorg Med Chem Lett 17: 4795-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.062 BindingDB Entry DOI: 10.7270/Q2JS9Q4D | |||||||||||
More data for this Ligand-Target Pair |