BDBM50218172 (R)-2-(2-(4-(2-cyclopentylthiazol-4-yl)phenoxy)ethylamino)-1-(pyridin-3-yl)ethanol::CHEMBL400392
SMILES: O[C@@H](CNCCOc1ccc(cc1)-c1csc(n1)C1CCCC1)c1cccnc1
InChI Key: InChIKey=ISJPANQFRQXZLQ-QFIPXVFZSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-1 adrenergic receptor (Homo sapiens (Human)) | BDBM50218172 ((R)-2-(2-(4-(2-cyclopentylthiazol-4-yl)phenoxy)eth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cells | Bioorg Med Chem Lett 17: 5245-50 (2007) Article DOI: 10.1016/j.bmcl.2007.06.072 BindingDB Entry DOI: 10.7270/Q2MK6CMZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-3 adrenergic receptor (Homo sapiens (Human)) | BDBM50218172 ((R)-2-(2-(4-(2-cyclopentylthiazol-4-yl)phenoxy)eth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 290 | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Agonist activity at human adrenergic beta-3 receptor expressed in CHO cells assessed as cAMP production | Bioorg Med Chem Lett 17: 5245-50 (2007) Article DOI: 10.1016/j.bmcl.2007.06.072 BindingDB Entry DOI: 10.7270/Q2MK6CMZ | |||||||||||
More data for this Ligand-Target Pair |