BDBM50218729 2-(4-hydroxy-3-methoxy-phenyl)-5,10-dihydro-dibenzo[b,e]-[1,4]diazepin-11-one::CHEMBL395816

SMILES: COc1cc(ccc1O)-c1ccc2Nc3ccccc3NC(=O)c2c1

InChI Key: InChIKey=JRMUTMZLTDYPTN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50218729   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50218729 (2-(4-hydroxy-3-methoxy-phenyl)-5,10-dihydro-dibenz...) Show SMILES COc1cc(ccc1O)-c1ccc2Nc3ccccc3NC(=O)c2c1 Show InChI InChI=1S/C20H16N2O3/c1-25-19-11-13(7-9-18(19)23)12-6-8-15-14(10-12)20(24)22-17-5-3-2-4-16(17)21-15/h2-11,21,23H,1H3,(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant Chk1				J Med Chem 50: 4162-76 (2007) Article DOI: 10.1021/jm070105d BindingDB Entry DOI: 10.7270/Q22J6BKS
					More data for this Ligand-Target Pair