BDBM50219272 (5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl)quinolin-5-yl)oxazol-4-yl)(4-hydroxy-4-phenylpiperidin-1-yl)methanone::CHEMBL437020

SMILES: COc1ccc(-c2nc(C(=O)N3CCC(O)(CC3)c3ccccc3)c(CN)o2)c2ccc(nc12)C(F)(F)F

InChI Key: InChIKey=MZLGPWMELUQSRS-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50219272   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 11A (Homo sapiens (Human))	BDBM50219272 ((5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl)q...) Show SMILES COc1ccc(-c2nc(C(=O)N3CCC(O)(CC3)c3ccccc3)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C27H25F3N4O4/c1-37-19-9-7-18(17-8-10-21(27(28,29)30)32-22(17)19)24-33-23(20(15-31)38-24)25(35)34-13-11-26(36,12-14-34)16-5-3-2-4-6-16/h2-10,36H,11-15,31H2,1H3	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of PDE11				Bioorg Med Chem Lett 17: 5150-4 (2007) Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50219272 ((5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl)q...) Show SMILES COc1ccc(-c2nc(C(=O)N3CCC(O)(CC3)c3ccccc3)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C27H25F3N4O4/c1-37-19-9-7-18(17-8-10-21(27(28,29)30)32-22(17)19)24-33-23(20(15-31)38-24)25(35)34-13-11-26(36,12-14-34)16-5-3-2-4-6-16/h2-10,36H,11-15,31H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of PDE10				Bioorg Med Chem Lett 17: 5150-4 (2007) Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H
					More data for this Ligand-Target Pair
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50219272 ((5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl)q...) Show SMILES COc1ccc(-c2nc(C(=O)N3CCC(O)(CC3)c3ccccc3)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C27H25F3N4O4/c1-37-19-9-7-18(17-8-10-21(27(28,29)30)32-22(17)19)24-33-23(20(15-31)38-24)25(35)34-13-11-26(36,12-14-34)16-5-3-2-4-6-16/h2-10,36H,11-15,31H2,1H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of PDE4B				Bioorg Med Chem Lett 17: 5150-4 (2007) Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H
					More data for this Ligand-Target Pair