Found 3 hits for monomerid = 50219275 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM50219275
(CHEMBL249691 | tert-butyl 4-(5-(aminomethyl)-2-(8-...)Show SMILES COc1ccc(-c2nc(C(=O)N3CCN(CC3)C(=O)OC(C)(C)C)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C25H28F3N5O5/c1-24(2,3)38-23(35)33-11-9-32(10-12-33)22(34)20-17(13-29)37-21(31-20)15-5-7-16(36-4)19-14(15)6-8-18(30-19)25(26,27)28/h5-8H,9-13,29H2,1-4H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE11 |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50219275
(CHEMBL249691 | tert-butyl 4-(5-(aminomethyl)-2-(8-...)Show SMILES COc1ccc(-c2nc(C(=O)N3CCN(CC3)C(=O)OC(C)(C)C)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C25H28F3N5O5/c1-24(2,3)38-23(35)33-11-9-32(10-12-33)22(34)20-17(13-29)37-21(31-20)15-5-7-16(36-4)19-14(15)6-8-18(30-19)25(26,27)28/h5-8H,9-13,29H2,1-4H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE10 |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |
3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50219275
(CHEMBL249691 | tert-butyl 4-(5-(aminomethyl)-2-(8-...)Show SMILES COc1ccc(-c2nc(C(=O)N3CCN(CC3)C(=O)OC(C)(C)C)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C25H28F3N5O5/c1-24(2,3)38-23(35)33-11-9-32(10-12-33)22(34)20-17(13-29)37-21(31-20)15-5-7-16(36-4)19-14(15)6-8-18(30-19)25(26,27)28/h5-8H,9-13,29H2,1-4H3 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 17: 5150-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H |
More data for this Ligand-Target Pair | |