BDBM50219277 4-(5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl)quinolin-5-yl)oxazole-4-carbonyl)-N,N-dimethylpiperazine-1-sulfonamide::CHEMBL249933

SMILES: COc1ccc(-c2nc(C(=O)N3CCN(CC3)S(=O)(=O)N(C)C)c(CN)o2)c2ccc(nc12)C(F)(F)F

InChI Key: InChIKey=YEYTXNAIKZAMCI-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50219277   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 11A (Homo sapiens (Human))	BDBM50219277 (4-(5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl...) Show SMILES COc1ccc(-c2nc(C(=O)N3CCN(CC3)S(=O)(=O)N(C)C)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C22H25F3N6O5S/c1-29(2)37(33,34)31-10-8-30(9-11-31)21(32)19-16(12-26)36-20(28-19)14-4-6-15(35-3)18-13(14)5-7-17(27-18)22(23,24)25/h4-7H,8-12,26H2,1-3H3	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of PDE11				Bioorg Med Chem Lett 17: 5150-4 (2007) Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50219277 (4-(5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl...) Show SMILES COc1ccc(-c2nc(C(=O)N3CCN(CC3)S(=O)(=O)N(C)C)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C22H25F3N6O5S/c1-29(2)37(33,34)31-10-8-30(9-11-31)21(32)19-16(12-26)36-20(28-19)14-4-6-15(35-3)18-13(14)5-7-17(27-18)22(23,24)25/h4-7H,8-12,26H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of PDE10				Bioorg Med Chem Lett 17: 5150-4 (2007) Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H
					More data for this Ligand-Target Pair
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50219277 (4-(5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl...) Show SMILES COc1ccc(-c2nc(C(=O)N3CCN(CC3)S(=O)(=O)N(C)C)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C22H25F3N6O5S/c1-29(2)37(33,34)31-10-8-30(9-11-31)21(32)19-16(12-26)36-20(28-19)14-4-6-15(35-3)18-13(14)5-7-17(27-18)22(23,24)25/h4-7H,8-12,26H2,1-3H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of PDE4B				Bioorg Med Chem Lett 17: 5150-4 (2007) Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H
					More data for this Ligand-Target Pair