BDBM50219278 CHEMBL250137::[5-aminomethyl-2-(8-methoxy-2-trifluoromethyl-quinolin-5-yl)-oxazol-4-yl]-[4-(5-methyl-1H-pyrazole-3-carbonyl)-piperazin-1-yl]-methanone

SMILES: COc1ccc(-c2nc(C(=O)N3CCN(CC3)C(=O)c3cc(C)n[nH]3)c(CN)o2)c2ccc(nc12)C(F)(F)F

InChI Key: InChIKey=KDJMRVWHETZTTP-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50219278   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 11A (Homo sapiens (Human))	BDBM50219278 (CHEMBL250137 | [5-aminomethyl-2-(8-methoxy-2-trifl...) Show SMILES COc1ccc(-c2nc(C(=O)N3CCN(CC3)C(=O)c3cc(C)n[nH]3)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C25H24F3N7O4/c1-13-11-16(33-32-13)23(36)34-7-9-35(10-8-34)24(37)21-18(12-29)39-22(31-21)15-3-5-17(38-2)20-14(15)4-6-19(30-20)25(26,27)28/h3-6,11H,7-10,12,29H2,1-2H3,(H,32,33)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of PDE11				Bioorg Med Chem Lett 17: 5150-4 (2007) Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H
					More data for this Ligand-Target Pair
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50219278 (CHEMBL250137 | [5-aminomethyl-2-(8-methoxy-2-trifl...) Show SMILES COc1ccc(-c2nc(C(=O)N3CCN(CC3)C(=O)c3cc(C)n[nH]3)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C25H24F3N7O4/c1-13-11-16(33-32-13)23(36)34-7-9-35(10-8-34)24(37)21-18(12-29)39-22(31-21)15-3-5-17(38-2)20-14(15)4-6-19(30-20)25(26,27)28/h3-6,11H,7-10,12,29H2,1-2H3,(H,32,33)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of PDE4B				Bioorg Med Chem Lett 17: 5150-4 (2007) Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50219278 (CHEMBL250137 | [5-aminomethyl-2-(8-methoxy-2-trifl...) Show SMILES COc1ccc(-c2nc(C(=O)N3CCN(CC3)C(=O)c3cc(C)n[nH]3)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C25H24F3N7O4/c1-13-11-16(33-32-13)23(36)34-7-9-35(10-8-34)24(37)21-18(12-29)39-22(31-21)15-3-5-17(38-2)20-14(15)4-6-19(30-20)25(26,27)28/h3-6,11H,7-10,12,29H2,1-2H3,(H,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of PDE10				Bioorg Med Chem Lett 17: 5150-4 (2007) Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H
					More data for this Ligand-Target Pair