BDBM50220277 1-((2R,6R)-1-(4-chlorophenylsulfonyl)-6-ethylpiperidin-2-yl)cyclopropyl 4-ethyl-4-hydroxypiperidine-1-carboxylate::CHEMBL392144

SMILES: CC[C@@H]1CCC[C@@H](N1S(=O)(=O)c1ccc(Cl)cc1)C1(CC1)OC(=O)N1CCC(O)(CC)CC1

InChI Key: InChIKey=IOUDUPKHXQXVDO-TZIWHRDSSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50220277   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta amyloid A4 protein (Homo sapiens (Human))	BDBM50220277 (1-((2R,6R)-1-(4-chlorophenylsulfonyl)-6-ethylpiper...) Show SMILES CC[C@@H]1CCC[C@@H](N1S(=O)(=O)c1ccc(Cl)cc1)C1(CC1)OC(=O)N1CCC(O)(CC)CC1 Show InChI InChI=1S/C24H35ClN2O5S/c1-3-19-6-5-7-21(27(19)33(30,31)20-10-8-18(25)9-11-20)24(12-13-24)32-22(28)26-16-14-23(29,4-2)15-17-26/h8-11,19,21,29H,3-7,12-17H2,1-2H3/t19-,21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of gamma-secretase assessed as reduction of membrane Abeta40 level				Bioorg Med Chem Lett 17: 5330-5 (2007) Article DOI: 10.1016/j.bmcl.2007.08.013 BindingDB Entry DOI: 10.7270/Q21G0KZB
					More data for this Ligand-Target Pair
Beta amyloid A4 protein (Homo sapiens (Human))	BDBM50220277 (1-((2R,6R)-1-(4-chlorophenylsulfonyl)-6-ethylpiper...) Show SMILES CC[C@@H]1CCC[C@@H](N1S(=O)(=O)c1ccc(Cl)cc1)C1(CC1)OC(=O)N1CCC(O)(CC)CC1 Show InChI InChI=1S/C24H35ClN2O5S/c1-3-19-6-5-7-21(27(19)33(30,31)20-10-8-18(25)9-11-20)24(12-13-24)32-22(28)26-16-14-23(29,4-2)15-17-26/h8-11,19,21,29H,3-7,12-17H2,1-2H3/t19-,21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of gamma-secretase assessed as reduction of cell Abeta40 level				Bioorg Med Chem Lett 17: 5330-5 (2007) Article DOI: 10.1016/j.bmcl.2007.08.013 BindingDB Entry DOI: 10.7270/Q21G0KZB
					More data for this Ligand-Target Pair