BDBM50220586 1-[2-hydroxy-2-(6-hydroxy-biphenyl-3-yl)-1-methyl-ethyl]-4-phenyl-piperidin-4-ol::6-(2-(4-(3-fluorophenyl)-4-hydroxypiperidin-1-yl)-1-hydroxyethyl)-3,4-dihydroquinolin-2(1H)-one::CHEMBL246819

SMILES: OC(CN1CCC(O)(CC1)c1cccc(F)c1)c1ccc2NC(=O)CCc2c1

InChI Key: InChIKey=ZTOSZJPNPROTBL-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50220586   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50220586 (1-[2-hydroxy-2-(6-hydroxy-biphenyl-3-yl)-1-methyl-...) Show SMILES OC(CN1CCC(O)(CC1)c1cccc(F)c1)c1ccc2NC(=O)CCc2c1 |w:1.0| Show InChI InChI=1S/C22H25FN2O3/c23-18-3-1-2-17(13-18)22(28)8-10-25(11-9-22)14-20(26)16-4-6-19-15(12-16)5-7-21(27)24-19/h1-4,6,12-13,20,26,28H,5,7-11,14H2,(H,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane				Bioorg Med Chem Lett 17: 5558-62 (2007) Article DOI: 10.1016/j.bmcl.2007.08.014 BindingDB Entry DOI: 10.7270/Q2R21138
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50220586 (1-[2-hydroxy-2-(6-hydroxy-biphenyl-3-yl)-1-methyl-...) Show SMILES OC(CN1CCC(O)(CC1)c1cccc(F)c1)c1ccc2NC(=O)CCc2c1 |w:1.0| Show InChI InChI=1S/C22H25FN2O3/c23-18-3-1-2-17(13-18)22(28)8-10-25(11-9-22)14-20(26)16-4-6-19-15(12-16)5-7-21(27)24-19/h1-4,6,12-13,20,26,28H,5,7-11,14H2,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Displacement of [3H]bufuralol from hERG channel expressed in HEK293 cells				Bioorg Med Chem Lett 17: 5558-62 (2007) Article DOI: 10.1016/j.bmcl.2007.08.014 BindingDB Entry DOI: 10.7270/Q2R21138
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50220586 (1-[2-hydroxy-2-(6-hydroxy-biphenyl-3-yl)-1-methyl-...) Show SMILES OC(CN1CCC(O)(CC1)c1cccc(F)c1)c1ccc2NC(=O)CCc2c1 |w:1.0| Show InChI InChI=1S/C22H25FN2O3/c23-18-3-1-2-17(13-18)22(28)8-10-25(11-9-22)14-20(26)16-4-6-19-15(12-16)5-7-21(27)24-19/h1-4,6,12-13,20,26,28H,5,7-11,14H2,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Displacement of [3H]bufuralol from hERG channel expressed in HEK293 cells				Bioorg Med Chem Lett 17: 5558-62 (2007) Article DOI: 10.1016/j.bmcl.2007.08.014 BindingDB Entry DOI: 10.7270/Q2R21138
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50220586 (1-[2-hydroxy-2-(6-hydroxy-biphenyl-3-yl)-1-methyl-...) Show SMILES OC(CN1CCC(O)(CC1)c1cccc(F)c1)c1ccc2NC(=O)CCc2c1 |w:1.0| Show InChI InChI=1S/C22H25FN2O3/c23-18-3-1-2-17(13-18)22(28)8-10-25(11-9-22)14-20(26)16-4-6-19-15(12-16)5-7-21(27)24-19/h1-4,6,12-13,20,26,28H,5,7-11,14H2,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Displacement of [3H]bufuralol from hERG channel expressed in HEK293 cells				Bioorg Med Chem Lett 17: 5558-62 (2007) Article DOI: 10.1016/j.bmcl.2007.08.014 BindingDB Entry DOI: 10.7270/Q2R21138
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50220586 (1-[2-hydroxy-2-(6-hydroxy-biphenyl-3-yl)-1-methyl-...) Show SMILES OC(CN1CCC(O)(CC1)c1cccc(F)c1)c1ccc2NC(=O)CCc2c1 |w:1.0| Show InChI InChI=1S/C22H25FN2O3/c23-18-3-1-2-17(13-18)22(28)8-10-25(11-9-22)14-20(26)16-4-6-19-15(12-16)5-7-21(27)24-19/h1-4,6,12-13,20,26,28H,5,7-11,14H2,(H,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane				Bioorg Med Chem Lett 17: 5558-62 (2007) Article DOI: 10.1016/j.bmcl.2007.08.014 BindingDB Entry DOI: 10.7270/Q2R21138
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50220586 (1-[2-hydroxy-2-(6-hydroxy-biphenyl-3-yl)-1-methyl-...) Show SMILES OC(CN1CCC(O)(CC1)c1cccc(F)c1)c1ccc2NC(=O)CCc2c1 |w:1.0| Show InChI InChI=1S/C22H25FN2O3/c23-18-3-1-2-17(13-18)22(28)8-10-25(11-9-22)14-20(26)16-4-6-19-15(12-16)5-7-21(27)24-19/h1-4,6,12-13,20,26,28H,5,7-11,14H2,(H,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.80	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane				Bioorg Med Chem Lett 17: 5558-62 (2007) Article DOI: 10.1016/j.bmcl.2007.08.014 BindingDB Entry DOI: 10.7270/Q2R21138
					More data for this Ligand-Target Pair