BDBM50220841 BMS-262084::CHEMBL71037
SMILES: [#6]C([#6])([#6])[#7]-[#6](=O)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-[#6](=O)-[#7]-1-[#6@@H](-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6]-1=O)-[#6](-[#8])=O
InChI Key: InChIKey=MFTQITSPGQORDA-NEPJUHHUSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tryptase (Homo sapiens (Human)) | BDBM50220841 (BMS-262084 | CHEMBL71037) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibitory activity of compound against human tryptase was determined | Bioorg Med Chem Lett 14: 2227-31 (2004) Article DOI: 10.1016/j.bmcl.2004.02.011 BindingDB Entry DOI: 10.7270/Q2GM86Q3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor XI (Homo sapiens (Human)) | BDBM50220841 (BMS-262084 | CHEMBL71037) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company Curated by ChEMBL | Assay Description Inhibition of human factor 11a using S-2366 substrate incubated for 3 mins by spectrophotometry | J Med Chem 61: 7425-7447 (2018) Article DOI: 10.1021/acs.jmedchem.8b00173 BindingDB Entry DOI: 10.7270/Q2QJ7KW0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptase delta (Homo sapiens (Human)) | BDBM50220841 (BMS-262084 | CHEMBL71037) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company Curated by ChEMBL | Assay Description Inhibition of human lung tryptase using Z-glypro-arg-AMC incubated for 3 mins by spectrophotometry | J Med Chem 61: 7425-7447 (2018) Article DOI: 10.1021/acs.jmedchem.8b00173 BindingDB Entry DOI: 10.7270/Q2QJ7KW0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trypsin (Homo sapiens (Human)) | BDBM50220841 (BMS-262084 | CHEMBL71037) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company Curated by ChEMBL | Assay Description Inhibition of trypsin (unknown origin) using Chromozyme-TRY substrate incubated for 3 mins by spectrophotometry | J Med Chem 61: 7425-7447 (2018) Article DOI: 10.1021/acs.jmedchem.8b00173 BindingDB Entry DOI: 10.7270/Q2QJ7KW0 | |||||||||||
More data for this Ligand-Target Pair |