BDBM50221085 (3R,4S)-1-(6-(3-fluorophenyl)pyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine::CHEMBL237343

SMILES: N[C@H]1CN(C[C@@H]1c1cc(F)c(F)cc1F)c1cc(ncn1)-c1cccc(F)c1

InChI Key: InChIKey=XDQKNXBLASGZHN-KDOFPFPSSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50221085   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dipeptidyl peptidase VIII (Homo sapiens (Human))	BDBM50221085 ((3R,4S)-1-(6-(3-fluorophenyl)pyrimidin-4-yl)-4-(2,...) Show SMILES N[C@H]1CN(C[C@@H]1c1cc(F)c(F)cc1F)c1cc(ncn1)-c1cccc(F)c1 Show InChI InChI=1S/C20H16F4N4/c21-12-3-1-2-11(4-12)19-7-20(27-10-26-19)28-8-14(18(25)9-28)13-5-16(23)17(24)6-15(13)22/h1-7,10,14,18H,8-9,25H2/t14-,18+/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human recombinant DPP8				Bioorg Med Chem Lett 17: 5638-42 (2007) Article DOI: 10.1016/j.bmcl.2007.07.081 BindingDB Entry DOI: 10.7270/Q2319WRX
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II) (Homo sapiens (Human))	BDBM50221085 ((3R,4S)-1-(6-(3-fluorophenyl)pyrimidin-4-yl)-4-(2,...) Show SMILES N[C@H]1CN(C[C@@H]1c1cc(F)c(F)cc1F)c1cc(ncn1)-c1cccc(F)c1 Show InChI InChI=1S/C20H16F4N4/c21-12-3-1-2-11(4-12)19-7-20(27-10-26-19)28-8-14(18(25)9-28)13-5-16(23)17(24)6-15(13)22/h1-7,10,14,18H,8-9,25H2/t14-,18+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human recombinant DPP2				Bioorg Med Chem Lett 17: 5638-42 (2007) Article DOI: 10.1016/j.bmcl.2007.07.081 BindingDB Entry DOI: 10.7270/Q2319WRX
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50221085 ((3R,4S)-1-(6-(3-fluorophenyl)pyrimidin-4-yl)-4-(2,...) Show SMILES N[C@H]1CN(C[C@@H]1c1cc(F)c(F)cc1F)c1cc(ncn1)-c1cccc(F)c1 Show InChI InChI=1S/C20H16F4N4/c21-12-3-1-2-11(4-12)19-7-20(27-10-26-19)28-8-14(18(25)9-28)13-5-16(23)17(24)6-15(13)22/h1-7,10,14,18H,8-9,25H2/t14-,18+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human recombinant DPP4				Bioorg Med Chem Lett 17: 5638-42 (2007) Article DOI: 10.1016/j.bmcl.2007.07.081 BindingDB Entry DOI: 10.7270/Q2319WRX
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50221085 ((3R,4S)-1-(6-(3-fluorophenyl)pyrimidin-4-yl)-4-(2,...) Show SMILES N[C@H]1CN(C[C@@H]1c1cc(F)c(F)cc1F)c1cc(ncn1)-c1cccc(F)c1 Show InChI InChI=1S/C20H16F4N4/c21-12-3-1-2-11(4-12)19-7-20(27-10-26-19)28-8-14(18(25)9-28)13-5-16(23)17(24)6-15(13)22/h1-7,10,14,18H,8-9,25H2/t14-,18+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human recombinant DPP4				Bioorg Med Chem Lett 17: 5638-42 (2007) Article DOI: 10.1016/j.bmcl.2007.07.081 BindingDB Entry DOI: 10.7270/Q2319WRX
					More data for this Ligand-Target Pair