Found 7 hits for monomerid = 50221517 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50221517
(6-methoxy-7-(2-methoxyethoxy)-4-((1R,2S)-2-phenylc...)Show SMILES COCCOc1cc2ncc(C#N)c(N[C@@H]3C[C@H]3c3ccccc3)c2cc1OC Show InChI InChI=1S/C23H23N3O3/c1-27-8-9-29-22-12-19-18(11-21(22)28-2)23(16(13-24)14-25-19)26-20-10-17(20)15-6-4-3-5-7-15/h3-7,11-12,14,17,20H,8-10H2,1-2H3,(H,25,26)/t17-,20+/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Research Laboratories USA, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant EGFR by fluorescence polarization assay |
Bioorg Med Chem Lett 17: 5978-82 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.071 BindingDB Entry DOI: 10.7270/Q2VM4C0N |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50221517
(6-methoxy-7-(2-methoxyethoxy)-4-((1R,2S)-2-phenylc...)Show SMILES COCCOc1cc2ncc(C#N)c(N[C@@H]3C[C@H]3c3ccccc3)c2cc1OC Show InChI InChI=1S/C23H23N3O3/c1-27-8-9-29-22-12-19-18(11-21(22)28-2)23(16(13-24)14-25-19)26-20-10-17(20)15-6-4-3-5-7-15/h3-7,11-12,14,17,20H,8-10H2,1-2H3,(H,25,26)/t17-,20+/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Research Laboratories USA, Inc.
Curated by ChEMBL
| Assay Description Inhibition of SRC |
Bioorg Med Chem Lett 17: 5978-82 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.071 BindingDB Entry DOI: 10.7270/Q2VM4C0N |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50221517
(6-methoxy-7-(2-methoxyethoxy)-4-((1R,2S)-2-phenylc...)Show SMILES COCCOc1cc2ncc(C#N)c(N[C@@H]3C[C@H]3c3ccccc3)c2cc1OC Show InChI InChI=1S/C23H23N3O3/c1-27-8-9-29-22-12-19-18(11-21(22)28-2)23(16(13-24)14-25-19)26-20-10-17(20)15-6-4-3-5-7-15/h3-7,11-12,14,17,20H,8-10H2,1-2H3,(H,25,26)/t17-,20+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Research Laboratories USA, Inc.
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 17: 5978-82 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.071 BindingDB Entry DOI: 10.7270/Q2VM4C0N |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50221517
(6-methoxy-7-(2-methoxyethoxy)-4-((1R,2S)-2-phenylc...)Show SMILES COCCOc1cc2ncc(C#N)c(N[C@@H]3C[C@H]3c3ccccc3)c2cc1OC Show InChI InChI=1S/C23H23N3O3/c1-27-8-9-29-22-12-19-18(11-21(22)28-2)23(16(13-24)14-25-19)26-20-10-17(20)15-6-4-3-5-7-15/h3-7,11-12,14,17,20H,8-10H2,1-2H3,(H,25,26)/t17-,20+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Research Laboratories USA, Inc.
Curated by ChEMBL
| Assay Description Inhibition of SYK |
Bioorg Med Chem Lett 17: 5978-82 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.071 BindingDB Entry DOI: 10.7270/Q2VM4C0N |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase ABL1
(Homo sapiens (Human)) | BDBM50221517
(6-methoxy-7-(2-methoxyethoxy)-4-((1R,2S)-2-phenylc...)Show SMILES COCCOc1cc2ncc(C#N)c(N[C@@H]3C[C@H]3c3ccccc3)c2cc1OC Show InChI InChI=1S/C23H23N3O3/c1-27-8-9-29-22-12-19-18(11-21(22)28-2)23(16(13-24)14-25-19)26-20-10-17(20)15-6-4-3-5-7-15/h3-7,11-12,14,17,20H,8-10H2,1-2H3,(H,25,26)/t17-,20+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 390 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Research Laboratories USA, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ABL |
Bioorg Med Chem Lett 17: 5978-82 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.071 BindingDB Entry DOI: 10.7270/Q2VM4C0N |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50221517
(6-methoxy-7-(2-methoxyethoxy)-4-((1R,2S)-2-phenylc...)Show SMILES COCCOc1cc2ncc(C#N)c(N[C@@H]3C[C@H]3c3ccccc3)c2cc1OC Show InChI InChI=1S/C23H23N3O3/c1-27-8-9-29-22-12-19-18(11-21(22)28-2)23(16(13-24)14-25-19)26-20-10-17(20)15-6-4-3-5-7-15/h3-7,11-12,14,17,20H,8-10H2,1-2H3,(H,25,26)/t17-,20+/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Research Laboratories USA, Inc.
Curated by ChEMBL
| Assay Description Inhibition of Flt1 |
Bioorg Med Chem Lett 17: 5978-82 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.071 BindingDB Entry DOI: 10.7270/Q2VM4C0N |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50221517
(6-methoxy-7-(2-methoxyethoxy)-4-((1R,2S)-2-phenylc...)Show SMILES COCCOc1cc2ncc(C#N)c(N[C@@H]3C[C@H]3c3ccccc3)c2cc1OC Show InChI InChI=1S/C23H23N3O3/c1-27-8-9-29-22-12-19-18(11-21(22)28-2)23(16(13-24)14-25-19)26-20-10-17(20)15-6-4-3-5-7-15/h3-7,11-12,14,17,20H,8-10H2,1-2H3,(H,25,26)/t17-,20+/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 52.8 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Research Laboratories USA, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human EGFR autophosphorylation in A431 cells |
Bioorg Med Chem Lett 17: 5978-82 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.071 BindingDB Entry DOI: 10.7270/Q2VM4C0N |
More data for this Ligand-Target Pair | |