BindingDB PrimarySearch

BDBM50221522 6-(4-(aminomethyl)phenyl)-4-((1R,2S)-2-phenylcyclopropylamino)quinoline-3-carbonitrile::CHEMBL245800

SMILES: NCc1ccc(cc1)-c1ccc2ncc(C#N)c(N[C@@H]3C[C@H]3c3ccccc3)c2c1

InChI Key: InChIKey=XZLGYNGUWUQCLQ-WIOPSUGQSA-N

Data: 6 KI 1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50221522
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50221522 (6-(4-(aminomethyl)phenyl)-4-((1R,2S)-2-phenylcyclo...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Research Laboratories USA, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant EGFR by fluorescence polarization assay				Bioorg Med Chem Lett 17: 5978-82 (2007) Article DOI: 10.1016/j.bmcl.2007.07.071 BindingDB Entry DOI: 10.7270/Q2VM4C0N
Tanabe Research Laboratories USA, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50221522 (6-(4-(aminomethyl)phenyl)-4-((1R,2S)-2-phenylcyclo...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	86	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Research Laboratories USA, Inc. Curated by ChEMBL					Assay Description Inhibition of SRC				Bioorg Med Chem Lett 17: 5978-82 (2007) Article DOI: 10.1016/j.bmcl.2007.07.071 BindingDB Entry DOI: 10.7270/Q2VM4C0N
Tanabe Research Laboratories USA, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50221522 (6-(4-(aminomethyl)phenyl)-4-((1R,2S)-2-phenylcyclo...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	450	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Research Laboratories USA, Inc. Curated by ChEMBL					Assay Description Inhibition of SYK				Bioorg Med Chem Lett 17: 5978-82 (2007) Article DOI: 10.1016/j.bmcl.2007.07.071 BindingDB Entry DOI: 10.7270/Q2VM4C0N
Tanabe Research Laboratories USA, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM50221522 (6-(4-(aminomethyl)phenyl)-4-((1R,2S)-2-phenylcyclo...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	770	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Research Laboratories USA, Inc. Curated by ChEMBL					Assay Description Inhibition of ABL				Bioorg Med Chem Lett 17: 5978-82 (2007) Article DOI: 10.1016/j.bmcl.2007.07.071 BindingDB Entry DOI: 10.7270/Q2VM4C0N
Tanabe Research Laboratories USA, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM50221522 (6-(4-(aminomethyl)phenyl)-4-((1R,2S)-2-phenylcyclo...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Research Laboratories USA, Inc. Curated by ChEMBL					Assay Description Inhibition of Flt1				Bioorg Med Chem Lett 17: 5978-82 (2007) Article DOI: 10.1016/j.bmcl.2007.07.071 BindingDB Entry DOI: 10.7270/Q2VM4C0N
Tanabe Research Laboratories USA, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50221522 (6-(4-(aminomethyl)phenyl)-4-((1R,2S)-2-phenylcyclo...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Research Laboratories USA, Inc. Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 17: 5978-82 (2007) Article DOI: 10.1016/j.bmcl.2007.07.071 BindingDB Entry DOI: 10.7270/Q2VM4C0N
Tanabe Research Laboratories USA, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50221522 (6-(4-(aminomethyl)phenyl)-4-((1R,2S)-2-phenylcyclo...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Research Laboratories USA, Inc. Curated by ChEMBL					Assay Description Inhibition of human EGFR autophosphorylation in A431 cells				Bioorg Med Chem Lett 17: 5978-82 (2007) Article DOI: 10.1016/j.bmcl.2007.07.071 BindingDB Entry DOI: 10.7270/Q2VM4C0N
Tanabe Research Laboratories USA, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair