BDBM50222417 4-(3,3-dimethyl-4-phenylbut-1-ynyl)-6,7-dimethoxyquinazoline::CHEMBL399953

SMILES: COc1cc2ncnc(C#CC(C)(C)Cc3ccccc3)c2cc1OC

InChI Key: InChIKey=RVEDAUKOXMSMKQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50222417   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50222417 (4-(3,3-dimethyl-4-phenylbut-1-ynyl)-6,7-dimethoxyq...) Show SMILES COc1cc2ncnc(C#CC(C)(C)Cc3ccccc3)c2cc1OC Show InChI InChI=1S/C22H22N2O2/c1-22(2,14-16-8-6-5-7-9-16)11-10-18-17-12-20(25-3)21(26-4)13-19(17)24-15-23-18/h5-9,12-13,15H,14H2,1-4H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Mitsubishi Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of partially purified EGFR tyrosine kinase from human A431 cells				Bioorg Med Chem Lett 17: 5863-7 (2007) Article DOI: 10.1016/j.bmcl.2007.08.020 BindingDB Entry DOI: 10.7270/Q2H70FJ7
					More data for this Ligand-Target Pair