BDBM50222437 1-(4-(6,7-diethoxyquinazolin-4-yl)-2-methyl-1-phenylbut-3-yn-2-yl)piperidine-4-carboxylic acid::CHEMBL251314

SMILES: CCOc1cc2ncnc(C#CC(C)(Cc3ccccc3)N3CCC(CC3)C(O)=O)c2cc1OCC

InChI Key: InChIKey=GRSVZOBWWBQUNG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50222437   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50222437 (1-(4-(6,7-diethoxyquinazolin-4-yl)-2-methyl-1-phen...) Show SMILES CCOc1cc2ncnc(C#CC(C)(Cc3ccccc3)N3CCC(CC3)C(O)=O)c2cc1OCC |w:12.12| Show InChI InChI=1S/C29H33N3O4/c1-4-35-26-17-23-24(30-20-31-25(23)18-27(26)36-5-2)11-14-29(3,19-21-9-7-6-8-10-21)32-15-12-22(13-16-32)28(33)34/h6-10,17-18,20,22H,4-5,12-13,15-16,19H2,1-3H3,(H,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11.7	n/a	n/a	n/a	n/a	n/a	n/a
Mitsubishi Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of partially purified EGFR tyrosine kinase from human A431 cells				Bioorg Med Chem Lett 17: 5863-7 (2007) Article DOI: 10.1016/j.bmcl.2007.08.020 BindingDB Entry DOI: 10.7270/Q2H70FJ7
					More data for this Ligand-Target Pair