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BDBM50222498 CHEMBL400512::N-(3,5-bis(trifluoromethyl)phenyl)-2-(pyridin-4-ylmethylamino)nicotinamide

SMILES: FC(F)(F)c1cc(NC(=O)c2cccnc2NCc2ccncc2)cc(c1)C(F)(F)F

InChI Key: InChIKey=GTODNZCUIOSWJB-UHFFFAOYSA-N

Data: 1 KI

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50222498   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222498
PNG
(CHEMBL400512 | N-(3,5-bis(trifluoromethyl)phenyl)-...)
Show SMILES FC(F)(F)c1cc(NC(=O)c2cccnc2NCc2ccncc2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C20H14F6N4O/c21-19(22,23)13-8-14(20(24,25)26)10-15(9-13)30-18(31)16-2-1-5-28-17(16)29-11-12-3-6-27-7-4-12/h1-10H,11H2,(H,28,29)(H,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
8n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of phosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
More data for this
Ligand-Target Pair