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BDBM50222509 CHEMBL250228::N-(4-chlorophenyl)-2-(pyridin-4-ylmethylamino)nicotinamide

SMILES: Clc1ccc(NC(=O)c2cccnc2NCc2ccncc2)cc1

InChI Key: InChIKey=NOSWLVYNWMYEPM-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50222509   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50222509
PNG
(CHEMBL250228 | N-(4-chlorophenyl)-2-(pyridin-4-ylm...)
Show SMILES Clc1ccc(NC(=O)c2cccnc2NCc2ccncc2)cc1
Show InChI InChI=1S/C18H15ClN4O/c19-14-3-5-15(6-4-14)23-18(24)16-2-1-9-21-17(16)22-12-13-7-10-20-11-8-13/h1-11H,12H2,(H,21,22)(H,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Patents

Article
PubMed
8n/an/an/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Inhibition of unphosphorylated-Kdr after 30 mins


Bioorg Med Chem Lett 17: 6003-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.077
More data for this
Ligand-Target Pair