BDBM50223033 3,6-diethyl-N-((1R,2S)-2-(2-fluoroethoxy)-2,3-dihydro-1H-inden-1-yl)-5-(6-methylpyrimidin-4-yloxy)pyrazin-2-amine::CHEMBL248996

SMILES: CCc1nc(Oc2cc(C)ncn2)c(CC)nc1N[C@H]1[C@H](Cc2ccccc12)OCCF

InChI Key: InChIKey=PFCPSCXSKDSMJY-RBBKRZOGSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50223033   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50223033 (3,6-diethyl-N-((1R,2S)-2-(2-fluoroethoxy)-2,3-dihy...) Show SMILES CCc1nc(Oc2cc(C)ncn2)c(CC)nc1N[C@H]1[C@H](Cc2ccccc12)OCCF Show InChI InChI=1S/C24H28FN5O2/c1-4-18-23(28-19(5-2)24(29-18)32-21-12-15(3)26-14-27-21)30-22-17-9-7-6-8-16(17)13-20(22)31-11-10-25/h6-9,12,14,20,22H,4-5,10-11,13H2,1-3H3,(H,28,30)/t20-,22+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	51	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [125I]Tyr-o-CRF from CRF1 receptor in IMR32 cells				Bioorg Med Chem Lett 17: 6250-6 (2007) Article DOI: 10.1016/j.bmcl.2007.09.008 BindingDB Entry DOI: 10.7270/Q2F76C8G
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