BDBM50223462 6-(3-aminopropyl)-4-bromo-9-(1H-pyrazol-4-yl)benzo[h]isoquinolin-1(2H)-one::CHEMBL249044

SMILES: NCCCc1cc2c(Br)c[nH]c(=O)c2c2cc(ccc12)-c1cn[nH]c1

InChI Key: InChIKey=QVNAEWDNNFUYSB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50223462   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50223462 (6-(3-aminopropyl)-4-bromo-9-(1H-pyrazol-4-yl)benzo...) Show SMILES NCCCc1cc2c(Br)c[nH]c(=O)c2c2cc(ccc12)-c1cn[nH]c1 Show InChI InChI=1S/C19H17BrN4O/c20-17-10-22-19(25)18-15-6-11(13-8-23-24-9-13)3-4-14(15)12(2-1-5-21)7-16(17)18/h3-4,6-10H,1-2,5,21H2,(H,22,25)(H,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human Chk1 expressed in baculovirus by time-resolved fluorescence assay				Bioorg Med Chem Lett 17: 6280-5 (2007) Article DOI: 10.1016/j.bmcl.2007.09.007 BindingDB Entry DOI: 10.7270/Q2W958ZJ
					More data for this Ligand-Target Pair