BDBM50224408 8-bromo-3-(4-chloro-phenyl)-9-methylamino-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one::CHEMBL241547

SMILES: CNc1c(Br)cnc2sc3c(ncn(-c4ccc(Cl)cc4)c3=O)c12

InChI Key: InChIKey=PFKFGKXVMKQDJI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50224408   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50224408 (8-bromo-3-(4-chloro-phenyl)-9-methylamino-3H-pyrid...) Show SMILES CNc1c(Br)cnc2sc3c(ncn(-c4ccc(Cl)cc4)c3=O)c12 Show InChI InChI=1S/C16H10BrClN4OS/c1-19-12-10(17)6-20-15-11(12)13-14(24-15)16(23)22(7-21-13)9-4-2-8(18)3-5-9/h2-7H,1H3,(H,19,20)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.90	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assay				J Med Chem 50: 5550-3 (2007) Article DOI: 10.1021/jm070590c BindingDB Entry DOI: 10.7270/Q2D50MQX
					More data for this Ligand-Target Pair