BDBM50224425 CHEMBL241118::N-[(3R)-6-(2-fluorophenyl)-2-oxoazepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide

SMILES: Fc1ccccc1C1CC[C@@H](NC(=O)N2CCC(CC2)n2c3cccnc3[nH]c2=O)C(=O)NC1

InChI Key: InChIKey=LLKYZEVAQYETNP-XCWJXAQQSA-N

Data: 1 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50224425   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
CGRP type 1 receptor (Homo sapiens (Human))	BDBM50224425 (CHEMBL241118 | N-[(3R)-6-(2-fluorophenyl)-2-oxoaze...) Show SMILES Fc1ccccc1C1CC[C@@H](NC(=O)N2CCC(CC2)n2c3cccnc3[nH]c2=O)C(=O)NC1 Show InChI InChI=1S/C24H27FN6O3/c25-18-5-2-1-4-17(18)15-7-8-19(22(32)27-14-15)28-23(33)30-12-9-16(10-13-30)31-20-6-3-11-26-21(20)29-24(31)34/h1-6,11,15-16,19H,7-10,12-14H2,(H,27,32)(H,28,33)(H,26,29,34)/t15?,19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	37	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]CGPR from human CL receptor expressed in HEK293 cells				J Med Chem 50: 5564-7 (2007) Article DOI: 10.1021/jm070668p BindingDB Entry DOI: 10.7270/Q28C9W02
					More data for this Ligand-Target Pair
CGRP type 1 receptor (Homo sapiens (Human))	BDBM50224425 (CHEMBL241118 | N-[(3R)-6-(2-fluorophenyl)-2-oxoaze...) Show SMILES Fc1ccccc1C1CC[C@@H](NC(=O)N2CCC(CC2)n2c3cccnc3[nH]c2=O)C(=O)NC1 Show InChI InChI=1S/C24H27FN6O3/c25-18-5-2-1-4-17(18)15-7-8-19(22(32)27-14-15)28-23(33)30-12-9-16(10-13-30)31-20-6-3-11-26-21(20)29-24(31)34/h1-6,11,15-16,19H,7-10,12-14H2,(H,27,32)(H,28,33)(H,26,29,34)/t15?,19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serum				J Med Chem 50: 5564-7 (2007) Article DOI: 10.1021/jm070668p BindingDB Entry DOI: 10.7270/Q28C9W02
					More data for this Ligand-Target Pair
CGRP type 1 receptor (Homo sapiens (Human))	BDBM50224425 (CHEMBL241118 | N-[(3R)-6-(2-fluorophenyl)-2-oxoaze...) Show SMILES Fc1ccccc1C1CC[C@@H](NC(=O)N2CCC(CC2)n2c3cccnc3[nH]c2=O)C(=O)NC1 Show InChI InChI=1S/C24H27FN6O3/c25-18-5-2-1-4-17(18)15-7-8-19(22(32)27-14-15)28-23(33)30-12-9-16(10-13-30)31-20-6-3-11-26-21(20)29-24(31)34/h1-6,11,15-16,19H,7-10,12-14H2,(H,27,32)(H,28,33)(H,26,29,34)/t15?,19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production				J Med Chem 50: 5564-7 (2007) Article DOI: 10.1021/jm070668p BindingDB Entry DOI: 10.7270/Q28C9W02
					More data for this Ligand-Target Pair