new BindingDB logo
myBDB logout

BDBM50224749 4-(6,7-dichloro-3H-imidazo[4,5-b]pyridin-2-yl)-N,N-dimethylbenzenamine::CHEMBL237573

SMILES: CN(C)c1ccc(cc1)-c1nc2ncc(Cl)c(Cl)c2[nH]1

InChI Key: InChIKey=OBBXDMUVNYZBPW-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50224749   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aurora kinase A


(Homo sapiens (Human))
BDBM50224749
PNG
(4-(6,7-dichloro-3H-imidazo[4,5-b]pyridin-2-yl)-N,N...)
Show SMILES CN(C)c1ccc(cc1)-c1nc2ncc(Cl)c(Cl)c2[nH]1
Show InChI InChI=1S/C14H12Cl2N4/c1-20(2)9-5-3-8(4-6-9)13-18-12-11(16)10(15)7-17-14(12)19-13/h3-7H,1-2H3,(H,17,18,19)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 250n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of Aurora A


Eur J Med Chem 46: 77-94 (2010)


Article DOI: 10.1016/j.ejmech.2010.10.017
BindingDB Entry DOI: 10.7270/Q25X296N
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50224749
PNG
(4-(6,7-dichloro-3H-imidazo[4,5-b]pyridin-2-yl)-N,N...)
Show SMILES CN(C)c1ccc(cc1)-c1nc2ncc(Cl)c(Cl)c2[nH]1
Show InChI InChI=1S/C14H12Cl2N4/c1-20(2)9-5-3-8(4-6-9)13-18-12-11(16)10(15)7-17-14(12)19-13/h3-7H,1-2H3,(H,17,18,19)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 250n/an/an/an/an/an/a



Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of aurora A kinase


Bioorg Med Chem Lett 17: 6567-71 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.076
BindingDB Entry DOI: 10.7270/Q27D2TVT
More data for this
Ligand-Target Pair