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SMILES: OCCOc1cc2OC\C=C/COc3nc(NC(=O)Nc2cc1Cl)cnc3C#N

InChI Key: InChIKey=VFJZMZOLQVZHNE-UPHRSURJSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50224892   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM50224892
PNG
((Z)-7-chloro-8-(2-hydroxy-ethoxy)-3-oxo-11,16-diox...)
Show SMILES OCCOc1cc2OC\C=C/COc3nc(NC(=O)Nc2cc1Cl)cnc3C#N |c:9|
Show InChI InChI=1S/C18H16ClN5O5/c19-11-7-12-15(8-14(11)28-6-3-25)27-4-1-2-5-29-17-13(9-20)21-10-16(23-17)24-18(26)22-12/h1-2,7-8,10,25H,3-6H2,(H2,22,23,24,26)/b2-1-
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n/an/a 1n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Chk1

Bioorg Med Chem Lett 17: 6593-601 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.063
BindingDB Entry DOI: 10.7270/Q2X067WT
More data for this
Ligand-Target Pair