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SMILES: Clc1cc2NC(=O)Nc3cnc(C#N)c(OC\C=C/COc2cc1OCCN1CCOCC1)n3

InChI Key: InChIKey=POANVRKYMQAYOV-UPHRSURJSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50224894   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM50224894
PNG
((Z)-7-chloro-8-(2-morpholin-4-yl-ethoxy)-3-oxo-11,...)
Show SMILES Clc1cc2NC(=O)Nc3cnc(C#N)c(OC\C=C/COc2cc1OCCN1CCOCC1)n3 |c:17|
Show InChI InChI=1S/C22H23ClN6O5/c23-15-11-16-19(12-18(15)33-10-5-29-3-8-31-9-4-29)32-6-1-2-7-34-21-17(13-24)25-14-20(27-21)28-22(30)26-16/h1-2,11-12,14H,3-10H2,(H2,26,27,28,30)/b2-1-
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n/an/a 1n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Chk1

Bioorg Med Chem Lett 17: 6593-601 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.063
BindingDB Entry DOI: 10.7270/Q2X067WT
More data for this
Ligand-Target Pair