BindingDB logo
myBDB logout

null

SMILES: CN(C)c1cc2OC\C=C/COc3nc(NC(=O)Nc2cc1Cl)cnc3C#N

InChI Key: InChIKey=GRXFZNCHQKGOHJ-ARJAWSKDSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50224898   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM50224898
PNG
((Z)-7-chloro-8-dimethylamino-3-oxo-11,16-dioxa-2,4...)
Show SMILES CN(C)c1cc2OC\C=C/COc3nc(NC(=O)Nc2cc1Cl)cnc3C#N |c:8|
Show InChI InChI=1S/C18H17ClN6O3/c1-25(2)14-8-15-12(7-11(14)19)22-18(26)24-16-10-21-13(9-20)17(23-16)28-6-4-3-5-27-15/h3-4,7-8,10H,5-6H2,1-2H3,(H2,22,23,24,26)/b4-3-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Chk1

Bioorg Med Chem Lett 17: 6593-601 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.063
BindingDB Entry DOI: 10.7270/Q2X067WT
More data for this
Ligand-Target Pair