new BindingDB logo
myBDB logout

BDBM50224986 2-{4-[1-(4-methyl-benzyl)-piperidin-4-ylmethoxy]-phenyl}-1H-benzoimidazole-5-carboxylic acid amide::CHEMBL398467

SMILES: Cc1ccc(CN2CCC(COc3ccc(cc3)-c3nc4ccc(cc4[nH]3)C(N)=O)CC2)cc1

InChI Key: InChIKey=RTMQHKNUQOBLFZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50224986   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase CHK2


(Homo sapiens (Human))
BDBM50224986
PNG
(2-{4-[1-(4-methyl-benzyl)-piperidin-4-ylmethoxy]-p...)
Show SMILES Cc1ccc(CN2CCC(COc3ccc(cc3)-c3nc4ccc(cc4[nH]3)C(N)=O)CC2)cc1
Show InChI InChI=1S/C28H30N4O2/c1-19-2-4-20(5-3-19)17-32-14-12-21(13-15-32)18-34-24-9-6-22(7-10-24)28-30-25-11-8-23(27(29)33)16-26(25)31-28/h2-11,16,21H,12-15,17-18H2,1H3,(H2,29,33)(H,30,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 70n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Chk2


Bioorg Med Chem Lett 17: 6467-71 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.098
BindingDB Entry DOI: 10.7270/Q2KP81XB
More data for this
Ligand-Target Pair