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BDBM50224990 2-(4-((1-acetylpiperidin-4-yl)methoxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide::CHEMBL400755

SMILES: CC(=O)N1CCC(COc2ccc(cc2)-c2nc3ccc(cc3[nH]2)C(N)=O)CC1

InChI Key: InChIKey=IKTGBDZWNJLCND-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50224990   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase CHK2


(Homo sapiens (Human))
BDBM50224990
PNG
(2-(4-((1-acetylpiperidin-4-yl)methoxy)phenyl)-1H-b...)
Show SMILES CC(=O)N1CCC(COc2ccc(cc2)-c2nc3ccc(cc3[nH]2)C(N)=O)CC1
Show InChI InChI=1S/C22H24N4O3/c1-14(27)26-10-8-15(9-11-26)13-29-18-5-2-16(3-6-18)22-24-19-7-4-17(21(23)28)12-20(19)25-22/h2-7,12,15H,8-11,13H2,1H3,(H2,23,28)(H,24,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 78n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Chk2


Bioorg Med Chem Lett 17: 6467-71 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.098
BindingDB Entry DOI: 10.7270/Q2KP81XB
More data for this
Ligand-Target Pair