BDBM50224992 2-(4-(4-hydroxycyclohexyloxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide::CHEMBL249569

SMILES: NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(OC2CCC(O)CC2)cc1

InChI Key: InChIKey=NMQTYYCKJZLFKI-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50224992   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase CHK2 (Homo sapiens (Human))	BDBM50224992 (2-(4-(4-hydroxycyclohexyloxy)phenyl)-1H-benzo[d]im...) Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(OC2CCC(O)CC2)cc1 |(11.67,-7.06,;13.01,-6.28,;13.01,-4.74,;14.34,-7.05,;14.34,-8.6,;15.67,-9.37,;17.01,-8.59,;18.48,-9.06,;19.38,-7.81,;18.47,-6.56,;17,-7.05,;15.67,-6.28,;20.92,-7.8,;21.7,-9.13,;23.23,-9.12,;24,-7.78,;25.54,-7.77,;26.3,-6.43,;27.83,-6.42,;28.59,-5.09,;27.82,-3.76,;28.59,-2.42,;26.28,-3.77,;25.51,-5.11,;23.21,-6.45,;21.68,-6.46,)| Show InChI InChI=1S/C20H21N3O3/c21-19(25)13-3-10-17-18(11-13)23-20(22-17)12-1-6-15(7-2-12)26-16-8-4-14(24)5-9-16/h1-3,6-7,10-11,14,16,24H,4-5,8-9H2,(H2,21,25)(H,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL					Assay Description Inhibition of human recombinant Chk2				Bioorg Med Chem Lett 17: 6467-71 (2007) Article DOI: 10.1016/j.bmcl.2007.09.098 BindingDB Entry DOI: 10.7270/Q2KP81XB
					More data for this Ligand-Target Pair